The Caetani Palace in Cisterna di Latina was built in 1560, at the behest of Bonifacio Caetani, and was completed in 1574. The palace, whose works were directed by the architect Francesco da Volterra, was erected on the ruins of the ancient fortress of the Frangipane family, of which it incorporated a square stone tower, the only building to have escaped earlier devastation.
The Caetani family made it their main residence and called in various famous artists to embellish the residence.